Subacute combined degeneration of the cord due to folate deficiency: response to methyl folate treatment.
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منابع مشابه
Subacute combined degeneration of the cord due to folate deficiency: response to methyl folate treatment.
Subacute combined degeneration of the cord is a rare complication of folate deficiency. Disturbance of methylation reactions in nervous tissue probably underlie subacute combined degeneration of the cord arising from folate as well as vitamin B12 deficiency. Methyl tetrahydrofolate is the form in which folic acid is transported into the CNS. Therefore methyl tetrahydrofolate treatment of the ne...
متن کاملSubacute combined degeneration of the cord, dementia and parkinsonism due to an inborn error of folate metabolism.
A 2-year-old girl with 5,10-methylenetetrahydrofolate reductase deficiency developed subacute combined degeneration of the cord and a leuco-encephalopathy which was confirmed at necropsy. Total folate concentrations in serum, red cells and CSF were markedly reduced whereas vitamin B12 concentrations were normal. In addition the patient had Parkinsonism and reduced concentrations of homovanillic...
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1 of 3 DESCRIPTION A previously healthy 82-year-old lady presented with abnormal sensation in her fi ngers which she described as ‘feeling like bananas’. There was an additional history of deteriorating handwriting and a sense of imbalance when walking dating back 6 months. She obtained a score of 26 out of 30 on the mini mental state examination. She had gait ataxia, being unable to perform ta...
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Subacute combined degeneration of the spinal cord (SCD) is often found in vitamin B-12 deficiency and typically shows hyperintensity on T2-weighted images of the lateral and posterior columns. The purpose of the study was to evaluate the use of conventional magnetic resonance examination in diagnosing SCD. Thirty-six patients were clinically confirmed and retrospectively analyzed; conventional ...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1986
ISSN: 0022-3050
DOI: 10.1136/jnnp.49.10.1203